Argentina Itinerary

A Couple for the Road — Itinerary Guide

The Perfect Argentina Itinerary

Two weeks covering Buenos Aires, the wine country of Mendoza, the glaciers of Patagonia, and the Iguazú Falls — the full range of what makes Argentina one of South America's most extraordinary travel destinations.

14Days
4Regions
FlightsPrimary Transport
Oct–AprBest Season
Trip at a Glance — 14-Day Itinerary
1–5
Buenos AiresTango, steak & city culture
6–8
MendozaMalbec at the foot of the Andes
9–12
PatagoniaGlaciers, peaks & wilderness
13–14
Iguazú FallsThe most powerful waterfall on earth

A Country That Gets Under Your Skin

Argentina is the travel destination that most consistently turns two-week visitors into people who stay two months. It is a country of extraordinary contrasts — the European sophistication of Buenos Aires and the raw wilderness of Patagonia are separated by four hours of flight time and several centuries of character. The food is among the finest in South America. The wine, particularly the Malbec of Mendoza, has earned a place at the world's finest tables. The landscapes run from the subtropical jungle of Iguazú in the north to the glaciers of Los Glaciares National Park in the south.

Argentina rewards travelers who give it time. A week here produces a surface impression. Two weeks begins to reveal the country's character — the specific quality of Porteño intellectual life, the seriousness with which Argentines approach eating and conversation, the beauty of the Andean foothills in the late afternoon light. Three weeks, for those who have it, starts to feel like the beginning of understanding something real.

This itinerary covers the four experiences that define Argentina at its finest: Buenos Aires, Mendoza, Patagonia, and Iguazú. It uses domestic flights to connect them because Argentina is a large country and the distances are not negotiable on a two-week trip. It makes specific choices about how to spend time in each place and defends those choices.

Currency note: Argentina has historically operated a complex currency situation with official and informal exchange rates that diverge significantly. Research current conditions before travel — the practical implications for budgeting and cash access change frequently and can affect your trip substantially. Check recent traveler forums for up-to-date information on the best legal methods for currency exchange.

Domestic Flights Are Not Optional

Argentina is 2,780 kilometers from its northern border to the southern tip of Patagonia — roughly the distance from London to Tehran. The bus network is excellent and comfortable for journeys of six to twelve hours, and for Buenos Aires to Mendoza (14 hours) it is a viable overnight option that saves a hotel night. But for Patagonia and Iguazú, domestic flights are the only practical choice on a two-week itinerary.

Aerolíneas Argentinas operates the most comprehensive domestic network and is generally reliable. LATAM Airlines Argentina and JetSMART offer competitive pricing on key routes. Book domestic flights as early as possible — prices increase significantly as departure approaches, and the Ushuaia and Calafate routes in summer (December through February) can sell out weeks ahead. The key routes for this itinerary are Buenos Aires (EZE or AEP) to Mendoza (MDZ), Mendoza to El Calafate (FTE), El Calafate to Puerto Iguazú (IGR), and Puerto Iguazú back to Buenos Aires.

Within Buenos Aires, the combination of the Subte (subway), ride-share apps (Cabify and Uber both operate), and taxis is sufficient for everything. The city is large and the neighborhoods that matter for visitors are spread across it — a taxi from San Telmo to Palermo takes 20–30 minutes and costs very little at any exchange rate that reflects reality.

Buenos Aires

Buenos Aires is one of the great cities of the Americas — a metropolis of 15 million people whose urban culture is more European in character than anywhere else in South America, built around a café culture of genuine intellectual seriousness, a food and wine tradition of exceptional quality, and a tango that is not a tourist export but an art form that emerged from the immigrant neighborhoods of this city specifically and exists nowhere else in the form it takes here.

Five days in Buenos Aires is the right allocation for a first visit. The city is large, the neighborhoods are distinct, and rushing between them produces a surface impression of a place that rewards a slower approach. Palermo has the restaurants and the nightlife. San Telmo has the antiques markets and the tango clubs. Recoleta has the cemetery that is one of Argentina's most visited monuments and the Belle Époque architecture that explains why the city was once called the Paris of South America. La Boca has the Caminito — touristic, yes, but genuinely colorful in a way that photographs consistently undersell.

Days 1–2
Arrival, San Telmo & Recoleta

Arrive and give yourself the first evening to adjust — Buenos Aires runs on a schedule that would exhaust most visitors if they attempted to match it immediately. Dinner before 9pm is eating early. The best tango shows start at 10pm. The milongas where real tango dancers go do not warm up until midnight. Resist the first-night temptation to do everything and instead find a parrilla in the neighborhood where you are staying and eat simply: a chorizo sandwich, a glass of Malbec, bread and chimichurri while you wait for the main to arrive from the asador.

Spend your second day in San Telmo — the oldest neighborhood in Buenos Aires, with colonial architecture, cobblestone streets, and the Sunday Feria de San Telmo antiques market that fills the streets around the Plaza Dorrego from morning until early evening. The market is good for browsing even if you have no intention of buying — leather goods, vintage silverware, old maps of Argentina, tango records, and the specific detritus of a century of Porteño bourgeois life. The Recoleta Cemetery, a 20-minute taxi ride north, contains the mausoleums of Buenos Aires's most prominent families in a dense grid of marble and bronze that is genuinely one of the most extraordinary cemeteries in the world. Evita Perón is buried here in the Duarte family vault — the flower-covered entrance is easy to find.

Days 3–4
Palermo, La Boca & the Asado

Palermo divides into sub-neighborhoods — Palermo Soho, Palermo Hollywood, Las Cañitas — each with a slightly different character but all sharing the quality of being the part of Buenos Aires where the best independent restaurants, bars, and design shops have concentrated in the past two decades. The Saturday market in the Plaza Serrano area is excellent for leather goods, jewelry, and the kind of Argentine crafts that do not feel like tourist kitsch.

La Boca is worth the taxi journey for the Caminito specifically — the short pedestrianized street of corrugated iron houses painted in vivid colors that has become Buenos Aires's most photographed streetscape. It is tourist-facing and it knows it, but the colors are real and the surrounding neighborhood, while rough, is navigable in daylight with attention. The Bombonera — Boca Juniors' stadium, one of the most atmospheric football grounds in the world — is adjacent. If attending a match is possible during your visit, do it. Boca-River on any calendar date is an experience of social intensity that has no equivalent in European football.

Allocate one evening specifically to a proper asado. Buenos Aires has hundreds of parrillas ranging from tourist-facing operations to neighborhood restaurants where the grill has been firing since dawn and the cuts are chosen by a parrillero who has been doing this for thirty years. The quality difference is significant. Ask your hotel concierge or apartment host where they actually eat, not where they send tourists. Order the short rib (asado de tira), the sweetbreads (mollejas) if you have any appetite for offal, and whatever the kitchen considers its best cut that evening. Drink Malbec from Mendoza. Do not rush.

Day 5
Tigre Delta Day Trip

An hour north of Buenos Aires by commuter train from Retiro station, the Tigre Delta is a vast river delta of channels, islands, and waterways where the Paraná River meets the Río de la Plata. Boat taxis and launch services navigate the delta's 14,000 kilometers of waterways, connecting communities that are accessible only by water. An afternoon on the delta — renting a kayak, taking a public launch to one of the island restaurants, or simply riding the tourist catamaran through the main channels — provides a glimpse of an Argentina that is completely unlike the city and completely unlike Patagonia: subtropical, green, humid, and alive in the way of places that have not been significantly modified by infrastructure.

Mendoza — Malbec at the Foot of the Andes

Mendoza is Argentina's wine capital and one of the most rewarding wine destinations in the world — not because the wines are necessarily the finest available anywhere, but because the combination of the wines, the setting (the Andes rising above the vineyards on clear days with a clarity that photographs consistently undersell), and the Mendocino approach to hospitality produces an experience that is specifically its own and not replicable elsewhere.

The city itself is pleasant and compact — tree-lined pedestrian streets, good restaurants, a central plaza and park system designed after the 1861 earthquake that destroyed the original city. But Mendoza's reason for existing, from a traveler's perspective, is the wine region that surrounds it, and the wine region is best understood through the wineries rather than through the city.

Day 6
Arrival & Luján de Cuyo

Fly from Buenos Aires to Mendoza — the flight takes approximately 1 hour 45 minutes. Arrive, check in, and spend the afternoon in Luján de Cuyo, the subregion immediately south of the city that produces some of Argentina's most celebrated Malbec. The high altitude (900–1,100 meters), the wide diurnal temperature range between the hot days and cold nights, and the specific gravelly alluvial soils of the region produce wines of concentration and freshness that the lower-altitude Malbec of the Maipú subregion does not match.

A half-day organized wine tour through Viator or a local operator is the most efficient way to visit three or four wineries with transport included — the wineries are spread across the region and require a car or driver to visit efficiently. Alternatively, renting a bike and cycling the Maipú wine route (flatter, more accessible by bike, slightly less prestigious than Luján de Cuyo but excellent value for the effort) is one of the most enjoyable afternoons available in the Mendoza region.

Days 7–8
Valle de Uco & the Andes

The Valle de Uco — 80 kilometers south of Mendoza city at elevations of 1,000–1,500 meters — is the most exciting wine subregion in Argentina and the one that serious wine travelers make the specific journey to see. The altitude produces a longer growing season, lower yields, and wines of greater complexity and aging potential than the lower-altitude regions. The landscape is also more dramatically beautiful — the Andes are closer and larger, the vineyards are carved into the hillside, and the light at this elevation has a quality that is specifically Andean.

Achaval Ferrer, Zuccardi Valle de Uco (whose restaurant is one of the finest in Argentina), Clos de los Siete, and Domaine Bousquet are all in the Valle de Uco. A day here — wine tasting in the morning, lunch at one of the winery restaurants, a walk through the vineyards in the afternoon — is the finest single day available in the Mendoza region and worth organizing properly in advance rather than improvising on arrival.

On your second Mendoza day, consider the Aconcagua road trip — the highway heading west from Mendoza toward the Chilean border passes through increasingly dramatic Andean scenery before reaching the base camp area for Aconcagua, at 6,960 meters the highest peak in the Western Hemisphere. You do not need to be a climber to appreciate this drive. The scale of the mountains from the valley floor produces a specific physical sensation of smallness that the Mendoza wine country, beautiful as it is, cannot generate.

Patagonia — Where the World Gets Very Quiet

Patagonia occupies the southern third of Argentina and roughly the same amount of collective imagination — the name alone carries an association with wilderness and remoteness that very few geographic regions can match. The reality, for travelers who make it here, is that the imagination was understating things. The landscapes of Los Glaciares National Park, the Torres del Paine complex across the border in Chile, and the Fitz Roy massif above the town of El Chaltén are among the most dramatic on earth — not dramatic in the way of the Alps, which are grand and domesticated by centuries of human habitation, but dramatic in the way of places that have not yet been fully processed by the human need to normalize extraordinary things.

Days 9–10
El Calafate & Perito Moreno Glacier

Fly from Mendoza to El Calafate — the gateway town for Los Glaciares National Park. El Calafate itself is a small tourist town of 20,000 people with limited intrinsic interest, but its position as the base for the Perito Moreno Glacier makes it one of the most visited places in Argentina. The glacier deserves this — it is one of the few advancing glaciers in the world (most are retreating), covers 250 square kilometers, and rises 60–70 meters above the surface of Lago Argentino in a wall of blue-white ice that advances, calves, and thunders into the lake in a continuous process that is genuinely dramatic to witness from the network of elevated walkways above the shoreline.

The standard Perito Moreno day trip from El Calafate covers the walkways and the viewing platforms and takes a full day. For visitors who want more, mini-trekking on the glacier surface — crampons provided, guided, genuine ice walking on a surface that is actively moving — is available through the park operators and is one of the more specific physical experiences available in Argentina. Ice trekking on a Patagonian glacier does not require technical expertise and does require a tolerance for cold and an ability to walk on uneven terrain.

Days 11–12
El Chaltén & the Fitz Roy Massif

El Chaltén is 220 kilometers north of El Calafate by road — a three-hour bus journey through Patagonian steppe that is itself one of the more desolate and beautiful drives in Argentina. The town (population: 1,500 in winter, several times that in summer) exists primarily as a base for trekking to the Fitz Roy massif — the cluster of granite peaks dominated by the 3,405-meter Cerro Fitz Roy, which is to Patagonia what the Matterhorn is to the Alps in terms of visual iconic status, except that the Fitz Roy is wilder and less domesticated and harder to get to.

The Laguna de los Tres trek — approximately 20 kilometers round trip, six to eight hours, significant elevation gain on the final ascent — reaches a glacial lake directly below the Fitz Roy with a view that is among the finest available in South America on a clear day. The weather in Patagonia changes rapidly and the summit is frequently in cloud; building at least two days in El Chaltén into the itinerary gives you two chances at clear conditions rather than one. The shorter Laguna Torre trek reaches a different glacial lake below the Cerro Torre — equally dramatic, slightly more accessible — and is a worthwhile second-day option if the Laguna de los Tres was completed the previous day.

Iguazú Falls

Iguazú Falls spans the border between Argentina and Brazil — the Argentine side (the better side for variety and immersion) and the Brazilian side (the better side for the single most panoramic view). On two days, see both. The Falls are the reason this final stop exists, and they justify the flight from Patagonia that adds a day of travel to reach them.

The scale is genuinely difficult to prepare for. Iguazú is 2.7 kilometers wide, composed of 275 individual falls, and carries five times the water volume of Niagara. The Garganta del Diablo (Devil's Throat) — the largest single cascade, a U-shaped curtain of white water 80 meters high and 150 meters wide — is approached by a walkway over the river that deposits you at the edge of the falls with spray and sound that makes conversation impossible. It is one of the loudest places on earth and one of the most physically overwhelming natural phenomena available to any traveler.

Day 13
Argentine Side — Full Immersion

The Argentine side of the park offers three circuits: the Upper Circuit (views from above the falls), the Lower Circuit (views from below and beside the falls, with the best spray exposure), and the Garganta del Diablo walkway (the most dramatic single experience in the park). All three together take a full day. The Lower Circuit in the morning when the light comes from the east — producing rainbows in the spray that persist for most of the morning — is the right way to begin. The Garganta walkway in the afternoon, when you have already understood the scale of the system and can appreciate the specific madness of standing at the edge of the largest fall. Boat tours that go directly under the falls are available and are genuinely extraordinary and genuinely wet — bring dry clothes.

Day 14
Brazilian Side & Return to Buenos Aires

The Brazilian side of Iguazú is in Foz do Iguaçu in Brazil — crossing the border is straightforward for most nationalities, taking approximately 30 minutes by taxi or shuttle from the Argentine town of Puerto Iguazú. The Brazilian park offers a single long walkway parallel to the falls that provides the panoramic view of the full system that the Argentine side, being inside the falls, cannot. The view from the end of the Brazilian walkway — the entire Iguazú system spread across the horizon, mist rising, the Garganta del Diablo visible as the dominant point in the composition — is the postcard image of Iguazú and it exists only from this angle on this side.

Return to Puerto Iguazú and fly back to Buenos Aires for a final night before departure. If your flight home leaves from Buenos Aires Ezeiza international airport, budget 90 minutes from the city center — traffic on the highway to Ezeiza is consistently underestimated by visitors who have not made the journey before.

Planning Notes
  • Book all domestic flights as early as possible — Argentine domestic routes price up significantly close to departure and the Calafate routes in peak season (December–February) sell out
  • October, November, March, and April are the best months for Argentina — summer (December–February) is peak season with peak prices and peak crowds at Patagonia; winter (June–August) closes some Patagonia infrastructure
  • Patagonia weather is genuinely unpredictable — build buffer days into the El Chaltén section specifically and do not plan to see the Fitz Roy summit on a single day with a flight the following morning
  • Altitude in Mendoza is not an issue — the wine region sits at 700–1,500 meters, well below the threshold for acclimatization concerns
  • Argentine dinner happens late — restaurants in Buenos Aires fill between 9 and 11pm; arriving at 7:30pm puts you in an empty room with attentive but puzzled service staff
  • The Argentine steak culture is real and the quality is genuinely extraordinary at good parrillas — do not leave the country without eating a properly grilled asado de tira at a neighborhood parrilla that is not on any tourist list
  • Research current currency conditions before travel — Argentina's financial situation has historically produced multiple exchange rate options with significant practical implications for travelers carrying USD or EUR

The Bottom Line

Argentina in two weeks is enough to understand that you want to come back. Buenos Aires alone could absorb a month without exhausting what it offers. Mendoza's wine country rewards a week of serious attention. Patagonia is a destination that serious trekkers spend entire seasons in. Iguazú Falls deserves more than two days. But the four-region circuit above gives you the full range of what Argentina actually is — the sophistication and the wilderness, the wine and the steak, the city that stays out until 4am and the mountain that no one has yet fully domesticated.

It will get under your skin. Most places don't. Argentina does.

Scroll to Top